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Annual Review of Biomedical Engineering

Volume 26, 2024

Fly Me to the Micron: Microtechnologies for Research

Abstract

Multicellular model organisms, such as (fruit fly), are frequently used in a myriad of biological research studies due to their biological significance and global standardization. However, traditional tools used in these studies generally require manual handling, subjective phenotyping, and bulk treatment of the organisms, resulting in laborious experimental protocols with limited accuracy. Advancements in microtechnology over the course of the last two decades have allowed researchers to develop automated, high-throughput, and multifunctional experimental tools that enable novel experimental paradigms that would not be possible otherwise. We discuss recent advances in microtechnological systems developed for small model organisms using as an example. We critically analyze the state of the field by comparing the systems produced for different applications. Additionally, we suggest design guidelines, operational tips, and new research directions based on the technical and knowledge gaps in the literature. This review aims to foster interdisciplinary work by helping engineers to familiarize themselves with model organisms while presenting the most recent advances in microengineering strategies to biologists.

Keyword(s): developmental biology, Drosophila melanogaster, lab on a chip, mechanobiology, microbotics, microfabrication
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2024-07-03
2024-07-04
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Fly Me to the Micron: Microtechnologies for Drosophila Research
Annual Review of Biomedical Engineering 26, 441 (2024); https://doi.org/10.1146/annurev-bioeng-050423-054647
/content/journals/10.1146/annurev-bioeng-050423-054647
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