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Annual Review of Immunology

Volume 42, 2024

The Multifaceted Role of Tissue-Resident Memory T Cells

Abstract

Regionalized immune surveillance relies on the concerted efforts of diverse memory T cell populations. Of these, tissue-resident memory T (T) cells are strategically positioned in barrier tissues, where they enable efficient frontline defense against infections and cancer. However, the long-term persistence of these cells has been implicated in a variety of immune-mediated pathologies. Consequently, modulating T cell populations represents an attractive strategy for novel vaccination and therapeutic interventions against tissue-based diseases. Here, we provide an updated overview of T cell heterogeneity and function across tissues and disease states. We discuss mechanisms of T cell–mediated immune protection and their potential contributions to autoimmune disorders. Finally, we examine how T cell responses might be durably boosted or dampened for therapeutic gain.

Keyword(s): CD8+ T cells, memory T cells, tissue immunity, tissue-resident memory T cells
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/content/journals/10.1146/annurev-immunol-101320-020220
2024-06-28
2024-06-30
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/content/journals/10.1146/annurev-immunol-101320-020220
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The Multifaceted Role of Tissue-Resident Memory T Cells
Annual Review of Immunology 42, 317 (2024); https://doi.org/10.1146/annurev-immunol-101320-020220
/content/journals/10.1146/annurev-immunol-101320-020220
/content/journals/10.1146/annurev-immunol-101320-020220
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