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Fast Pressure-Sensitive Paint for Flow and Acoustic Diagnostics: Supplemental Video 6
A supplemental video from the 2014 review by James W. Gregory Hirotaka Sakaue Tianshu Liu and John P. Sullivan "Fast Pressure-Sensitive Paint for Flow and Acoustic Diagnostics" from the Annual Review of Fluid Mechanics.
Pressure coefficient distribution on the suction surface of a two-dimensional wing-profile model (NLR 7301 model) in pitch oscillation obtained by using polymer/ceramic pressure-sensitive paint at Mach 0.72.
Adjoint Equations in Stability Analysis: Supplemental Video 3
A supplemental video from the 2014 review by Paolo Luchini and Alessandro Bottaro "Adjoint Equations in Stability Analysis" from the Annual Review of Fluid Mechanics.
Structural sensitivity map of the secondary instability of the cylinder wake mode B (Re = 260) calculated as in Giannetti et al. (2010a). The structural sensitivity of this mode is a function of two spatial coordinates and a periodic function of time just as its base flow is. The sensitivity peak marks the location of the wave maker and its motion during the oscillation period showing that this structural sensitivity is even more localized (at each instant of time) than the sensitivity of the primary instability (Figure 6 of the article). The three material closed orbits of the primary instability are superimposed on the sensitivity map.
Retinoblastoma: Saving Life with Vision: Supplemental Video 2
A supplemental video from the 2014 review by David H. Abramson "Retinoblastoma: Saving Life with Vision" from the Annual Review of Medicine.
The catheter is passed through the carotid artery on the side to be treated beyond the exit of the ophthalmic artery. The catheter is not passed directly into the ophthalmic artery at this point.
Role of Hepatic Efflux Transporters in Regulating Systemic and Hepatocyte Exposure to Xenobiotics: Supplemental Video 1
A supplemental video from the 2014 review by Nathan D. Pfeifer Rhiannon N. Hardwick and Kim L.R. Brouwer "Role of Hepatic Efflux Transporters in Regulating Systemic and Hepatocyte Exposure to Xenobiotics" from the Annual Review of Pharmacology and Toxicology.
Bile canalicular contractions in sandwich-cultured rat hepatocytes. Sandwich-cultured hepatocytes are dynamic functional cells that exhibit motility throughout the cytoplasm when viewed by confocal microscopy. Note that the black line is located in the center of the open bile canalicular lumen and movements in the pericanalicular region (arrow) occur prior to and during contractions resulting in closure of open canaliculi. This behavior is consistent with previously published reports that isolated hepatocytes (couplets/hepatocyte groups) in the early stages of monolayer formation exhibited intact tight junctions with regular ordered contraction and slow refilling of bile canaliculi (see Reference A below); canalicular contractions were forceful and expelled luminal contents into the medium (see References A–C below). This supplemental video was produced by Daniel Bow PhD with the assistance of the Fluorescence Microscopy and Imaging Center at the National Institute of Environmental Health Sciences.
References
A. Oshio C Phillips MJ. 1981. Contractility of bile canaliculi: implications for liver function. Science 212:1041–42
B. Phillips MJ Oshio C Miyairi M Katz H Smith CR. 1982. A study of bile canalicular contractions in isolated hepatocytes. Hepatology 2:763–68
C. Boyer JL Gautam A Graf J. 1988. Mechanisms of bile secretion: insights from the isolated rat hepatocyte couplet. Semin. Liver Dis. 8:308–16
Retinoblastoma: Saving Life with Vision: Supplemental Video 1
A supplemental video from the 2014 review by David H. Abramson "Retinoblastoma: Saving Life with Vision" from the Annual Review of Medicine.
A 450-micron catheter is passed from the femoral artery up through the abdominal aorta thoracic aorta and internal carotid artery on the side to be treated.
Adjoint Equations in Stability Analysis: Supplemental Video 2
A supplemental video from the 2014 review by Paolo Luchini and Alessandro Bottaro "Adjoint Equations in Stability Analysis" from the Annual Review of Fluid Mechanics.
Structural sensitivity map of the secondary instability of the cylinder wake mode A (Re = 190) calculated as in Giannetti et al. (2010a). The structural sensitivity of this mode is a function of two spatial coordinates and a periodic function of time just as its base flow is. The sensitivity peak marks the location of the wave maker and its motion during the oscillation period showing that this structural sensitivity is even more localized (at each instant of time) than the sensitivity of the primary instability (Figure 6 of the article). The three material closed orbits of the primary instability are superimposed on the sensitivity map.
Retinoblastoma: Saving Life with Vision: Supplemental Video 3
A supplemental video from the 2014 review by David H. Abramson "Retinoblastoma: Saving Life with Vision" from the Annual Review of Medicine.
The catheter is then pulled back and because it is a flow-guided catheter it enters the orifice of the ophthalmic artery. Contrast dye confirms the position and the choroidal blush of the eye is clearly seen.
Adjoint Equations in Stability Analysis: Supplemental Video 1
A supplemental video from the 2014 review by Paolo Luchini and Alessandro Bottaro "Adjoint Equations in Stability Analysis" from the Annual Review of Fluid Mechanics.
Spatial evolution of the minimal seed in a boundary layer. The structure evolves with the initial downstream tilting of the low streamwise velocity region (in light blue) by the Orr mechanism the formation of a Λ structure and the subsequent creation of a hairpin vortex (visualized in gray through isosurfaces of the Q-criterion). This hairpin can rapidly induce downstream a train of smaller-scale hairpin vortices which display embedded within further small minimal seeds; this leads to a repeated sequence of the same events taking place over shorter length scales and timescales until turbulence (Cherubini et al. 2011 2012).
A Lecture in Psychology: The Psychology of Change: Self-Affirmation and Social Psychological Intervention
Geoffrey L. Cohen Professor in Stanford University’s Graduate School of Education Department of Psychology and (by courtesy) the Graduate School of Business and David Sherman Professor of Psychological and Brain Sciences at the University of California Santa Barbara talk about their article "The Psychology of Change: Self-Affirmation and Social Psychological Intervention" which they wrote together for the 2014 Annual Review of Psychology. In this lecture the explain how self-affirmation affects social and education outcomes. Focusing on values affirmation in which people write about values they hold dear they show how short inexpensive exercises can help counter the effects of stress and improve performance in members of certain socioeconomic categories.
A Lecture in Psychology: Is Adolescence a Sensitive Period for Sociocultural Processing?
Kathryn L. Mills of the Institute of Cognitive Neuroscience at the University College of London (UCL) talks about her article "Is Adolescence a Sensitive Period for Sociocultural Processing?" which she wrote with Sarah-Jayne Blakemore also of UCL for the 2014 Annual Review of Psychology.
In this lecture Ms. Mills argues that "studies about adolescence should include measures of social influence" as social context drives many of the decisions made by adolescents. She describes how the structure and function of the social brain continue to develop during the second decade of life and explains these changes must be taken into account.
A Lecture in Psychology: Working Memory: Theories, Models, and Controversies
Alan Baddeley Professor of Psychology at the University of York talks about his autobiographical article "Working Memory: Theories Models and Controversies" which he wrote for the 2012 Annual Review of Psychology. In this lecture Dr. Baddeley describes the evolving approaches to understanding memory over the course of the 20th century and how he came to develop the multicomponent approach to working memory as a theoretical framework. He then links it to long-term memory perception and action and explains how they interact.
A Lecture in Psychology: Deviance and Dissent in Groups
Jolanda Jetten Professor of Psychology at the University of Queensland talks about her article "Deviance and Dissent in Groups" which she wrote with Matthew J. Hornsey also of the University of Queensland for the 2014 Annual Review of Psychology. Dr. Jetten explores the reasons why people engage in deviance and dissent in groups a little-researched aspect of psychology as historically the discipline has been more focused on explaining the reasons for conformity in groups. Concentrating on a single section of her article Dr. Jetten describes the five motives for deviance and dissent from disengagement and disloyalty to the group to moral rebellion to tangible rewards.
A Lecture in Cell and Developmental Biology: Mechanobiology and Developmental Control
Donald E. Ingber Founding Director of the Wyss Institute Judah Folkman Professor of Vascular Biology at Harvard Medical School and Professor of Bioengineering at the Harvard School of Engineering and Applied Sciences talks about his article "Mechanobiology and Developmental Control" which he wrote with Tadanori Mammoto and Akiko Mammoto for the 2013 Annual Review of Cell and Developmental Biology. He discusses the role of physical and mechanical forces in the control of cell development and disease which he says is as important as chemicals and genes.
A Conversation with Eric F. Wieschaus
Eric Wieschaus Squibb Professor in Molecular Biology at Princeton University talks with Bonnie Bassler his colleague at Princeton and the Editor of the Annual Review of Genetics about his life and career. Dr. Wieschaus describes his beginnings as a young boy in Alabama and recounts how his interest in science was sparked by a science camp in Kansas funded by the National Science Foundation when he was a teenager. After a bachelor's degree at Notre Dame Dr. Wieschaus was admitted to graduate school at Yale University where he studied under the direction of Swiss Developmental Biologist Walter Gehring. Dr. Gehring eventually returned to his home country taking his student with him. In Basel Dr. Wieschaus met Christiane Nüsslein-Volhard or "Janni" as he calls her and together they began the work that defined their careers. Their research resulted in the identification of 139 genes that determine the development of fruit fly embryos (Drosophila melanogaster) a finding that earned them the 1995 Nobel Prize in Physiology or Medicine jointly with Edward B. Lewis.
A Conversation with Sydney Brenner
Dr. Sydney Brenner Senior Distinguished Fellow of the Crick-Jacobs Center at the Salk Institute talks about his life and career with Dr. Aravinda Chakravarti Director of the Center for Complex Disease Research at the McKusick-Nathans Institute of Genetic Medicine part of the Johns Hopkins University School of Medicine and co-Editor of the Annual Review of Genomics and Human Genetics. Dr. Brenner recounts his early life in South Africa and how he became interested in molecular biology came to work with Francis Crick at Cambridge University proposed the existence of messenger RNA and studied Caenorhabditis elegans as a model of neural development. The latter earned him the 2002 Nobel Prize in Physiology and Medicine.
A Conversation with Nevin Scrimshaw
Dr. Nevin Scrimshaw Institute Professor Emeritus of Nutrition and Food Science at the Massachusetts Institute of Technology talks about his life and career with his former student Cutberto Garza director of the Division of Nutritional Sciences at Cornell University. Dr. Scrimshaw discusses how he discovered a compound potassium iodate that allowed Central American salt to be iodized thereby preventing goiter a swelling of the thyroid in children. He also explains how he helped fight protein vitamin A and iron deficiencies in other parts of the developing world. Dr. Scrimshaw created the Institute of Nutrition in Central America and Panama and he founded the World Hunger Programme at the United Nations University the International Nutrition Foundation the Protein Advisory Group at the World Health Organization and UNICEF. He was also instrumental in identifying and explaining the link between nutrition and infection. Sadly Dr. Scrimshaw passed away on February 8 2013. We were honored to capture this conversation on video in August 2012.
A Conversation with Leonard and Leonore Herzenberg
Leonard and Leonore Herzenberg have left an indelible mark on the fields of immunology and cell biology both in research and clinical aspects. They are perhaps best known for developing the technologies of fluorescence flow cytometry and hybridomas. Over six decades they made a number of important and fundamental discoveries in lymphocyte biology by applying these technologies. During this era they immersed themselves in the sociopolitical environment interjecting scientific rationale into public discourse about McCarthyism nuclear fallout war genetics and other politically charged topics. Their unique philosophy has shaped their lives their science and ultimately the scientific community. In this Conversation we explore some of these driving forces and the impact on the laboratory.
A Lecture in Animal Biosciences: Making Slaughterhouses More Humane for Cattle, Pigs, and Sheep
Temple Grandin Professor of Animal Sciences at Colorado State University Fort Collins talks about her 2013 article "Making Slaughterhouses More Humane for Cattle Pigs and Sheep" which she wrote for the first volume of the Annual Review of Animal Biosciences. Dr. Grandin describes the best practices in preslaughter handling various stunning techniques and religious slaughter. She also explains how to enforce humane rules and methods so as to ensure the best possible treatment of animals.
Active Properties of Neocortical Pyramidal Neuron Dendrites: Supplemental Video 1
A supplemental video from the 2013 review by Guy Major Matthew E. Larkum and Jackie Schiller "Active Properties of Neocortical Pyramidal Neuron Dendrites" from the Annual Review of Neuroscience.
The supplemental movies show time evolution of I-V curves and membrane potential (Vm) of models following a brief pulse of glutamate with AMPAR conductances yielding just subthreshold and just-suprathreshold responses. Pale orange line in top panel and X in bottom right panel indicate threshold when bistable state exists.
In Supplemental Videos 1 and 2 the highest gmax NMDA = 5 × leak. Video 1: gmax AMPA = 2.1 × leak (subthreshold). Video 2: gmax AMPA = 2.2 × leak (suprathreshold). Would see small spike ‘riding on’ big subthreshold response (if superimposed).
Active Properties of Neocortical Pyramidal Neuron Dendrites: Supplemental Video 2
A supplemental video from the 2013 review by Guy Major Matthew E. Larkum and Jackie Schiller "Active Properties of Neocortical Pyramidal Neuron Dendrites" from the Annual Review of Neuroscience.
The supplemental movies show time evolution of I-V curves and membrane potential (Vm) of models following a brief pulse of glutamate with AMPAR conductances yielding just subthreshold and just-suprathreshold responses. Pale orange line in top panel and X in bottom right panel indicate threshold when bistable state exists.
In Supplemental Videos 1 and 2 the highest gmax NMDA = 5 × leak. Video 1: gmax AMPA = 2.1 × leak (subthreshold). Video 2: gmax AMPA = 2.2 × leak (suprathreshold). Would see small spike ‘riding on’ big subthreshold response (if superimposed).