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This volume of the Annual Review of Biochemistry contains three reviews on current developments in membrane protein research: Grigoryan et al. “Transmembrane Communication: General Principles and Lessons from the Structure and Function of the M2 Proton Channel, K+ Channels, and Integrin Receptors,” Hagan et al. “β-Barrel Membrane Protein Assembly by the Bam Complex,” and Dalbey et al. “Assembly of Bacterial Inner Membrane Proteins.” In this short introduction, I discuss these reviews in the larger context of where the field of membrane protein biochemistry is heading.
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Figure 2: A composite model of BamA constructed by superposition of two alternative structures of the five BamA POTRA domains with the FhaC outer membrane β-barrel protein and its single POTRA domain (7). The POTRA domains project into the periplasm.
Figure 3: Pyrococcus furiosus SecYEβ (8). Note the partially open lateral gate that spans across the entire width of the inner membrane.