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Annual Review of Biochemistry

Volume 67, 1998

TGF-β SIGNAL TRANSDUCTION

Abstract

The transforming growth factor β (TGF-β) family of growth factors control the development and homeostasis of most tissues in metazoan organisms. Work over the past few years has led to the elucidation of a TGF-β signal transduction network. This network involves receptor serine/threonine kinases at the cell surface and their substrates, the SMAD proteins, which move into the nucleus, where they activate target gene transcription in association with DNA-binding partners. Distinct repertoires of receptors, SMAD proteins, and DNA-binding partners seemingly underlie, in a cell-specific manner, the multifunctional nature of TGF-β and related factors. Mutations in these pathways are the cause of various forms of human cancer and developmental disorders.

Keyword(s): cancer, development, growth factors, receptor serine/threonine kinases, SMADs, TGF-β
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1998-07-01
2024-07-03
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TGF-β SIGNAL TRANSDUCTION
Annual Review of Biochemistry 67, 753 (1998); https://doi.org/10.1146/annurev.biochem.67.1.753
/content/journals/10.1146/annurev.biochem.67.1.753
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